Which type of NSAID selectively blocks COX-2 and is known as an anti-inflammatory?

The correct response identifies selective NSAIDs as those that specifically target the cyclooxygenase-2 (COX-2) enzyme, which plays a significant role in the inflammatory response. These agents are designed to reduce inflammation while minimizing gastrointestinal side effects typically associated with non-selective NSAIDs, which inhibit both COX-1 and COX-2.

Selective COX-2 inhibitors are often preferred for their anti-inflammatory effects and lower risk of causing stomach ulcers or gastrointestinal bleeding compared to non-selective NSAIDs. This is particularly beneficial for patients who may be at higher risk for such side effects.

In contrast, non-selective NSAIDs block both COX-1 and COX-2, which can lead to unwanted gastrointestinal effects. Antiplatelet agents primarily serve to inhibit platelet aggregation rather than function as anti-inflammatories. Sedatives do not have any relevance to the inhibition of cyclooxygenase enzymes and are used primarily to induce calmness or sleep. Therefore, the distinction of selective NSAIDs effectively highlights their targeted mechanism in treating inflammation while respecting the delicate balance of side effects.