NPTE Pharmacology Practice Test

Question: 1 / 400

Which of the following drugs is NOT considered a non-selective NSAID?

Naproxen

Ibuprofen

Celecoxib

Celecoxib is the correct choice because it is a selective COX-2 inhibitor, which differentiates it from non-selective NSAIDs. Non-selective NSAIDs, such as naproxen, ibuprofen, and aspirin, inhibit both COX-1 and COX-2 enzymes. This inhibition can lead to gastrointestinal side effects, as COX-1 is responsible for producing protective gastric mucosa. In contrast, celecoxib selectively inhibits COX-2, which is primarily involved in inflammation and pain, thus providing analgesic and anti-inflammatory effects while minimizing some of the gastrointestinal risks associated with non-selective NSAIDs. This selective action is particularly significant for patients who are at a higher risk for gastrointestinal complications.

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Aspirin

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