Which of the following is a potential side effect of methotrexate therapy?

Methotrexate is an antimetabolite and anti-inflammatory agent commonly used in the treatment of various conditions, including certain cancers, autoimmune diseases, and chronic inflammatory disorders. One known side effect associated with methotrexate therapy is nephrotoxicity.

Methotrexate is primarily excreted by the kidneys, and its cytotoxic effects can be exacerbated by compromised renal function. Inadequate hydration and renal impairment can lead to increased concentrations of methotrexate in the bloodstream, heightening the risk for toxicity. Nephrotoxicity can manifest as elevated serum creatinine levels or acute kidney injury, especially in high-dose methotrexate regimens or when renal function is already compromised.

Understanding the pharmacokinetics of methotrexate is crucial for monitoring and managing potential side effects, particularly regarding renal health. Awareness of this side effect can guide healthcare providers in taking precautionary measures, such as ensuring proper hydration before and during therapy and closely monitoring kidney function.

While the other options may represent side effects of different medications or conditions, they are not typically associated with methotrexate therapy, making nephrotoxicity the correct answer in this context.