Which medication class is associated with an increase in PR interval?

The correct answer refers to beta blockers, which are known to prolong the PR interval on an electrocardiogram (ECG). This effect is primarily due to the action of beta blockers on the sinoatrial (SA) and atrioventricular (AV) nodes within the heart. By blocking beta-adrenergic receptors, these medications reduce the conduction velocity through the AV node, leading to a delay in atrial impulses reaching the ventricles. This delay is observed as an increased PR interval.

Beta blockers are commonly used to manage conditions such as hypertension, heart failure, and certain arrhythmias, and understanding their impact on the PR interval is important in monitoring patients for potential cardiac issues.

In contrast, calcium channel blockers can similarly affect heart rate and conduction but typically do so in a way that may not exclusively prolong the PR interval—it can depend on the specific type of calcium channel blocker used and its mechanism of action. Diuretics mainly influence fluid excretion and have little effect on cardiac conduction, while alpha agonists primarily stimulate alpha-adrenergic receptors, which does not directly impact the PR interval.