What is one of the main side effects of ACE inhibitors?

The main side effect of ACE inhibitors is a persistent dry cough, which occurs in a notable percentage of patients who take these medications. This cough is believed to result from the accumulation of bradykinin, a peptide that ACE inhibitors prevent from being broken down. While dizziness, fatigue, and nausea can occur with ACE inhibitors, they are less commonly associated with this class of drugs.

The cough side effect can be quite bothersome for some patients, leading them to discontinue the medication. Understanding this effect is crucial for healthcare professionals, as they need to monitor for such reactions in patients and potentially consider alternative medications if the cough becomes intolerable.