What is a side effect commonly associated with thiazide diuretics?

Thiazide diuretics are commonly prescribed to manage hypertension and edema. One of the significant side effects associated with thiazide use is hypercalcemia, or elevated levels of calcium in the blood. This occurs because thiazide diuretics decrease calcium excretion by the kidneys, leading to an increased retention of calcium. In patients on thiazide therapy, it's important to monitor electrolyte levels, as hypercalcemia can result in various adverse effects, including kidney stones and impaired renal function.

In contrast, other side effects listed, such as hypoglycemia, bradycardia, and respiratory distress, are not typically associated with thiazide diuretics. Hypoglycemia is more commonly linked to other medications, particularly those used for diabetes management. Bradycardia may be associated with certain heart medications, and respiratory distress is not a common effect of thiazide diuretics. Therefore, recognizing hypercalcemia as a side effect is important for effective monitoring and management in patients receiving thiazide treatment.