What is a risk factor associated with using corticosteroids?

Corticosteroids are a class of steroid hormones that are often used to reduce inflammation and suppress the immune system. One significant risk factor associated with their use is the development of Cushing syndrome. This condition arises due to excessive levels of cortisol, a naturally occurring corticosteroid in the body. When corticosteroids are administered in high doses or for prolonged periods, they can mimic the effects of cortisol, leading to symptoms characteristic of Cushing syndrome. These symptoms may include weight gain, changes in mood, increased blood sugar, and skin changes.

The other options, while they may relate to other conditions or medications, are not primary concerns with corticosteroid use. Hypoglycemia is more commonly associated with insulin or certain diabetes medications rather than corticosteroids. Liver failure is not directly linked as a side effect of corticosteroid therapy, although the liver does metabolize these drugs. Diarrhea is not a typical consequence of corticosteroid use; instead, corticosteroids may sometimes cause gastrointestinal issues, but diarrhea is not a prominent risk. Thus, the connection between corticosteroids and Cushing syndrome highlights the need for careful management and monitoring of patients receiving these medications.