What is a key side effect of clindamycin?

Clindamycin is associated with a notable side effect that involves Clostridium difficile-associated diarrhea. This antibiotic affects the normal flora of the gastrointestinal tract, particularly when it disrupts the balance of bacteria in the gut. The decrease in beneficial bacteria allows for overgrowth of Clostridium difficile, a bacterium that can cause severe diarrhea and colitis. This side effect is significant because it can lead to serious health complications, prompting the need for monitoring patients on clindamycin for signs of gastrointestinal disturbances.

While nausea and vomiting, rash and itching, and kidney toxicity can occur with various medications, they are not the hallmark concern with clindamycin. Specifically, the risk of developing a C. difficile infection makes awareness of this side effect crucial for healthcare providers and patients alike. Recognizing the signs of this potential complication allows for timely intervention, which is key in managing the adverse effects of antibiotic therapy.