What is a major side effect of long-term corticosteroid use?

Long-term corticosteroid use is well-recognized for causing significant weight gain. This occurs due to several mechanisms, including increased appetite and alterations in metabolism, leading to fat redistribution. Corticosteroids can promote glycogenesis and fat deposition, particularly in the abdominal area, which contributes to the pronounced weight gain often seen in patients receiving prolonged steroid therapy.

In addition to weight gain, other common side effects of long-term corticosteroid use include osteoporosis, hypertension, and hyperglycemia; however, the direct link between corticosteroids and weight gain makes it a hallmark concern for healthcare providers and patients alike. It's essential for individuals on these medications to be monitored for weight changes and to implement strategies for managing weight as part of their overall treatment plan.