What effect does baclofen have on spasticity?

Baclofen is a central nervous system depressant that is primarily used as a muscle relaxant. It acts on the GABA-B receptors in the spinal cord, leading to the inhibition of neurotransmitter release which ultimately reduces the excitability of neurons. This action results in a decrease in muscle tone and spasticity, making baclofen an effective treatment for conditions characterized by increased muscle tone, such as multiple sclerosis or spinal cord injuries.

Thus, when baclofen is administered, it helps to alleviate the uncomfortable and sometimes painful involuntary muscle contractions associated with spasticity, providing significant relief to patients. The therapeutic effect of reducing spasticity helps improve mobility and comfort, making it a go-to medication in managing these specific neuromuscular situations.